DNA Microarrays in Herbal Drug Research
نویسندگان
چکیده
Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.
منابع مشابه
Application of DNA microarrays in occupational health research.
The profiling of gene expression patterns with DNA microarrays is recently being widely used not only in basic molecular biological studies but also in the practical fields. In clinical application, for example, this technique is expected to be quite useful in making a correct diagnosis. In the pharmacological area, the microarray analysis can be applied to drug discovery and individualized dru...
متن کاملGenetic Markers - A Cutting-Edge Technology in Herbal Drug Research
There is a great demand for herbal medicines in the developed and developing countries because of their wide biological activity, higher safety margin than synthetic drugs as a result of this Herbal drugs have a great potential in the global market. Herbal drug technology is used for converting botanicals materials into medicines, where standardization and quality control with proper integratio...
متن کاملModulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.
In the protozoan parasite Leishmania, drug resistance can be a complex phenomenon. Several metabolic pathways and membrane transporters are implicated in the resistance phenotype. To monitor the expression of these genes, we generated custom DNA microarrays with PCR fragments corresponding to 44 genes involved with drug resistance. Transcript profiling of arsenite and antimony resistant mutants...
متن کاملSignificance of Molecular Markers and DNA Based Technology in Research
BACKGROUND: There is a global as well national resurgence and revival of faith in drugs of plant origins. WHO has played a significant role in recognizing the relevance of these in today’s world. Herbal formulations and traditional medicines are generally polyherbal consisting of numerous bio-molecules because of which their identification and characterization is difficult. Also there are simil...
متن کاملA Consolidated Approach to Analyzing Data from High-Throughput Protein Microarrays with an Application to Immune Response Profiling in Humans
MOTIVATION DNA microarrays are a well-known and established technology in biological and pharmaceutical research providing a wealth of information essential for understanding biological processes and aiding drug development. Protein microarrays are quickly emerging as a follow-up technology, which will also begin to experience rapid growth as the challenges in protein to spot methodologies are ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Evidence-based Complementary and Alternative Medicine
دوره 3 شماره
صفحات -
تاریخ انتشار 2006